Dr. Craig E. Wheelock
Associate Professor. Craig Wheelock Karolinska Institutet

Project description

This project aim will investigate the effect of microbiota-derived lipid mediators produced from dietary fatty acids upon the gut mucosa. In particular, the 18-carbon fatty acids (e.g., linoleic and alpha-linolenic acid) are metabolized by the gut microbiota into downstream lipid mediators collectively called octadecanoids (analogous to the 20-carbon containing eicosanoids).

These compounds can exert potent biological functions in pro- and anti-inflammatory processes and recent studies have demonstrated a role of these gut microbial-derived products in several pathologies. Studies will focus on the role of these metabolites in intestinal development and barrier function in vivo. This project will use in vivo zebrafish-based models and murine small intestine organoids combined with high-throughput platforms to interrogate the function of microbiota-derived octadecanoids in the modulation of intestinal development.

What will this grant bring to the research project?

Grant support from the Biocodex Microbiota Foundation is vital for the initiation of this novel project. There is little information to date on these novel octadecanoid lipid mediators. Accordingly, the support from the Foundation in the early phases of the project makes it possible for us to initiate this project and generate preliminary results.

Nordics' winning projects

Pr. Päivi Tammela
2022 Nordics winner (Finland)Pr. Päivi Tammela

Improving the efficacy of L-dopa therapy of Parkinson’s disease through inhibiting L-dopa conversion to dopamine by intestinal bacteria

Associate prof. Thaher Pelaseyed
2022 Nordics winner (Sweden)Associate Professor. Thaher Pelaseyed

Role of breast milk mucins in regulation of infant gut microbiota and health

2021 Nordics winner (Estonia)Dr. Olli-Pekka Aukusti

Characterization of a novel potential probiotic strain of Lactobacillus salivarius and its association with Helicobacter pylori

2020 Nordics winner (Latvia)Pr. Daiga Santare

Effect of the Nordic diet on composition and functional profile of faecal microbiota and symptoms of fatigue in patients with mild and moderate ulcerative colitis

Pr. Ignacio Rangel
2020 Nordics winnerPr. Ignacio Rangel

Regulation of gene expression in gut bacteria host microRNAs

Anne Salonen
2018 Nordics winner 1Pr. Anne Salonen

Gut microbiota in relation to early growth and development of childhood obesity

Finland flag
2018 Nordics winner 2Dr. Veera Kainulainen

Commensal bacteria in the attenuation of intestinal inflammation - molecular mechanisms of functionality of isolated novel strains