Project description
Depression has emerged as a significant societal burden globally and the increasing prevalence of depression has also led to an increase in the use of antidepressants. In recent years, there is accumulating evidence for a strong impact of many human-targeted drugs on the composition of the gut microbiota. In light of these studies, it has become clear that medications likely confound many microbiome-disease associations.
Our project aims to investigate the associations between the gut microbiome, depression, and antidepressants using longitudinal gut microbiome anda health data from a subset of individuals within the Estonian Microbiome (EstMB) cohor. Taking into account the history of antidepressant use allows us to explain additional inter-individual variability and provides important insights to distinguish depression-specific changes in the microbiome from antidepressant-induced changes.
Associate Professor. Elin Org
What will this grant bring to your research project?
The outcomes of this project will advance our understanding of the effects of drugs and disease on the gut microbiome, thus enabling the development of new hypotheses for drug-host-microbiome interactions in depression.
Nordics' winning projects
Effect of novel microbiota-derived octadecanoid lipid Mediators and their functional impact on the gut mucosa
Improving the efficacy of L-dopa therapy of Parkinson’s disease through inhibiting L-dopa conversion to dopamine by intestinal bacteria
Role of breast milk mucins in regulation of infant gut microbiota and health
Characterization of a novel potential probiotic strain of Lactobacillus salivarius and its association with Helicobacter pylori
Regulation of gene expression in gut bacteria host microRNAs
Alteration of gut microbiota by Helicobacter pylori leading to the progression of liver diseases
Precision health approaches through machine learning of faecal microbiome data
Effect of the Nordic diet on composition and functional profile of faecal microbiota and symptoms of fatigue in patients with mild and moderate ulcerative colitis
Gut microbiota in relation to early growth and development of childhood obesity
Commensal bacteria in the attenuation of intestinal inflammation - molecular mechanisms of functionality of isolated novel strains