Associate prof. Thaher Pelaseyed
Associate Professor. Thaher Pelaseyed Göteborgs universitet, Department of Medical Biochemistry and Cell Biology

Project description

Each year acute enteric infections kill around 500,000 children under the age of 5.

Moreover, early-life exposure to antibiotics is associated with chronic diseases such as asthma, allergies and obesity, which are on the rise in developed countries. Since disruption of the microbiota in the infant gut is at the center of these global diseases, there is an urgent need to understand how beneficial bacterial communities are established and maintained in infants.

This proposal is the first-ever attempt to utilize breast milk mucins in promoting gut bacteria in infants, with the aim of enforcing intestinal defenses against acute infections and chronic diseases.

What will this grant bring to the research project?

It is widely recognized that breast milk promotes beneficial bacteria in the infant gut, however there is a critical knowledge gap regarding the specific impact of breast milk mucins on bacteria and intestinal defenses.

By deep profiling of the infant gut microbiota, we expect to identify specific bacteria that are supported by breast milk mucins and to determine if milk mucins can promote commensal colonization resistance against enteric pathogens. Moreover, we aim to understand if breast milk mucins support specific bacterial species required for the function of intestinal barriers in infants.

Nordics' winning projects

Dr. Craig E. Wheelock
2023 Nordics winnerAssociate Professor. Craig Wheelock

Effect of novel microbiota-derived octadecanoid lipid Mediators and their functional impact on the gut mucosa

Pr. Päivi Tammela
2022 Nordics winner (Finland)Pr. Päivi Tammela

Improving the efficacy of L-dopa therapy of Parkinson’s disease through inhibiting L-dopa conversion to dopamine by intestinal bacteria

2021 Nordics winner (Estonia)Dr. Olli-Pekka Aukusti

Characterization of a novel potential probiotic strain of Lactobacillus salivarius and its association with Helicobacter pylori

2020 Nordics winner (Latvia)Pr. Daiga Santare

Effect of the Nordic diet on composition and functional profile of faecal microbiota and symptoms of fatigue in patients with mild and moderate ulcerative colitis

Pr. Ignacio Rangel
2020 Nordics winnerPr. Ignacio Rangel

Regulation of gene expression in gut bacteria host microRNAs

Anne Salonen
2018 Nordics winner 1Pr. Anne Salonen

Gut microbiota in relation to early growth and development of childhood obesity

Finland flag
2018 Nordics winner 2Dr. Veera Kainulainen

Commensal bacteria in the attenuation of intestinal inflammation - molecular mechanisms of functionality of isolated novel strains