USA 2017 USA Grant Winner
Microbiota-directed therapies in chronic intestinal disease
Dr Rashim Singh, University of Houston
Flavonoids and Microbiome Interactions via Triple Recycling and their Roles in Food-borne Carcinogen-induced Colorectal Cancer
Our research aims towards exploring the bidirectional relationship between flavonoids and gut microbiome in the prevention of colorectal cancer induced by the dietary carcinogens (such as PhIP). In addition, our research will add to the building knowledge of xenobiotics-gut microbiome interaction, especially for the drugs undergoing phase-II metabolism and entering any component of triple recycling pathways. At last, this research might provide insights into finding solutions for gastrointestinal toxicity/side effects, such as severe diarrhea case of irinotecan and diclofenac, caused due to the generation of toxic molecules after the hydrolysis of glucuronides by microbial beta-glucuronidase.